Tag Archives: PKPD

“A creative modeling exercise resulting in significant gain in insight…”

An article by Dr Akpa and colleagues in the Department of Anesthesiology has been the subject of an upcoming editorial in the journal Anesthesiology. Dr. Geoffrey Tucker writes that the combination of complex small animal experiments and physiological modeling reported:

“… should be applauded as a creative modeling exercise resulting in significant gain in insight into the mechanisms of lipid resuscitation which opens the way for further investigation of the optimal clinical implementation …”

See the rest of the editorial here and see our paper here.

NSF-supported research sheds light on the role of fat infusions in reversing poison-induced heart failure

Recovery without CPRA little oil in your veins could prevent loss-of-life.  As the rate of death due to unintentional poisoning outstrips that associated with motor vehicle accidents, the need for efficient antidotes is increasingly urgent. Our lab is working to accelerate the development of a potential broad-spectrum antidote by implementing mathematical models at molecular and organism scales and integrating these with the experimental findings of physician-scientists.

NSF Grant 1228035