EMRLab at ACS Colloids 2015

We’re taking our work to the 89th ACS Colloids and Surface Science Symposium. A talk entitled “Anticoagulant incorporation in lipid bilayers indicates a biophysical mechanism for differential toxicity” will showcase the efforts of PhD student Manuela Ayee and undergraduate student Chuck Roth. The work is part of a larger effort to characterize and develop countermeasures against superwarfarin toxicity (NIH U01NS083457). 9:50AM Wednesday, June 17th @ 7500 Wean Hall, Carnegie Mellon University

Prof Akpa wins the College of Engineering’s Harold Simon Award!

UIC-Harold-Simon2Prof Akpa has been selected as the 2015 Harold Simon awardee.  The Harold Simon award is the highest teaching distinction in the College of Engineering:

“The late Dr. Harold A. Simon was a UIC professor of mechanical engineering renowned for his teaching excellence. In 1985, as a memorial to Dr. Simon, an award recognizing teaching excellence was established by the College of Engineering. One award is presented each year to a faculty member who exemplifies the dedication, distinguished service, and teaching excellence that were the hallmarks of the late Dr. Simon’s career.”

The award was presented to Prof Akpa by Dr Simon’s daughter during the College of Engineering commencement ceremonies on Saturday, May 9th.

Interrogating lipid dosing using physiological models – New publication at Annals of Emergency Medicine

confusion about infusionIntravenous infusions of lipid emulsion hold considerable promise as broad spectrum interventions for drug overdose, but one can have too much of a good thing.  Very high doses of lipid present their own complications, and our current understanding of lipid interventions is largely limited to reversal of acute heart failure in the case of a rapidly absorbed toxin.  The corresponding rates of IV delivery are likely not appropriate for treatment of oral overdoses where absorption of the cardiotoxin is prolonged.  See the article at Annals of Emergency Medicine.

tl;dr version: physiological models demonstrate the dynamic coupling of lipid metabolism with circulatory transport to explain why generic application of a fixed rate of infusion is potentially dangerous.

Latest publication is the cover story at the Journal of Controlled Release

JCRCheck out our latest on the multifunctionality of therapeutic emulsions: Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion

Via a combination of small-animal experiments and computational modelling, we highlight a 3-fold mechanism for the rapid reversal of toxin-induced cardiac instability.  These suspensions achieve the dual objective of stimulating cardiac contractility and displacing the offending xenobiotic from cardiac tissue.

Come see us at AIChE!

BHB sys

The group will have two presentations at this year’s meeting.  PhD student Manuela Ayee will be presenting her work on the structural consequences of metabolite absorption in lipid layers in a Tuesday morning session on the Thermophysical Properties of Biological Systems.  Prof Akpa will contribute a Rapid Fire Oral presentation and poster on Monday evening in the CAST Division’s Interactive Session on Applied Mathematics and Numerical Analysis.