Predicting Inter-individual Variability During Lipid Resuscitation of Bupivacaine Cardiotoxicity in Rats: A Virtual Population Modeling Study
Matthew McDaniel, Kevin Flores, Belinda Akpa
“Using the exemplar of bupivacaine systemic toxicity and a PBPK-PD model in rats, we have demonstrated how limited physiological data can inform a model that predicts population outcomes of lipid therapy.”
In this paper, we combined mechanistic modeling, machine learning, and causal analysis to predict resuscitation outcomes across a virtual population and characterize the relative contributions of pharmacokinetic and pharmacodynamic mechanisms to improved survival outcomes.